Category: Transient Plane Source
Author(s): Bryan Newman, Gerald B. Kasting, Jinsong Hao, Michael Murawsky, Priyanka Ghosh, Qian Zhang, S. Kevin Li, Sam G. Raney, Terri LaCount
Keywords: Heat effect, In vitro permeation test (IVPT), Temperature, Thermal Conductivity, Transdermal, Transdermal delivery system (TDS), Transient Plane Source, Transient plane source (TPS) method
Abstract: Elevated temperatures enhance the drug delivering ability of many transdermal delivery systems (TDS). This paper uses an in vivo method to examine the effects of heightened temperature on TDS, which can be applied to in vitro research. A Thermal Constants Analyzer measured the thermal conductivity and thermal resistivity of the TDS using the transient plane source (TPS) method at 40°C. The experimental in vivo thermal resistivity results for skin were agreeable with the values that were calculated using the thermal conductivity data. The temperature difference between the skin and TDS increased with thickness of TDS because it caused more thermal resistance.
Reference: Pharmaceutical Research, 34, 7 (2017) 1491-1504
DOI: 10.1007/s11095-017-2171-x